Oral and pharmaceutical microbiome

Evaluate the impact of your oral treatments on the oral microbiome

The oral microbiome, a key player in oral health

The oral microbiome is one of the most complex ecosystems in the body, harboring over 700 microbial species: bacteria, yeasts, viruses, archaea, and protozoa.

This ecosystem, dominated by genera such as Streptococcus, Veillonella, and Lactobacillus, performs several essential functions: (1–3)

Protection against pathogens through competition for adhesion sites;
Participation in digestion: they facilitate the breakdown of food and the transformation of certain nutrients.

When this balance is disrupted, dysbiosis can promote the development of oral and dental diseases:

Caries: fermentation of sugars by Streptococcus sp. and Lactobacillus → production of acids that demineralize enamel.
Gingivitis and periodontitis: proliferation of anaerobic bacteria such as Porphyromonas gingivalis or Treponema denticola.
Oral candidiasis: overgrowth of Candida albicans in the context of an imbalance or immunosuppression.
Halitosis: protein degradation by anaerobes (Fusobacterium, Prevotella, Veillonella).

Maintaining this balance is therefore a central challenge for pharmaceutical companies developing drugs, devices, or oral care products.

Sources :

Santacroce L, Passarelli PC, Azzolino D, Bottalico L, Charitos IA, Cazzolla AP, et al. Oral microbiota in human health and disease: A perspective. Exp Biol Med Maywood NJ. août 2023;248(15):1288‑301.
Baker JL, Mark Welch JL, Kauffman KM, McLean JS, He X. The oral microbiome: diversity, biogeography and human health. Nat Rev Microbiol. févr 2024;22(2):89‑104.
Hampelska K, Jaworska MM, Babalska ZŁ, Karpiński TM. The Role of Oral Microbiota in Intra-Oral Halitosis. J Clin Med. 2 août 2020;9(8):2484.

Studying biofilms to understand and prevent imbalances

In the oral cavity, microorganisms organize themselves into complex biofilms that adhere to teeth, the tongue, or mucous membranes.

Healthy biofilms → thin, stable, and protective against pathogens.
Unbalanced biofilms → plaque accumulation, local acidification, and gingival inflammation.

At BYOME LABS, we have unique expertise in analyzing the biofilm form, which is the natural organization of microorganisms.

In vitro culture on supports that replicate tooth surfaces,
Use of artificial saliva and simulation of physiological conditions (pH, flow, nutrition),
Measurement of the impact of your products or active ingredients on the microorganisms of the oral microbiome.

These models allow for the precise characterization of the effects of an active ingredient, device, or medication on the microbial processes involved in caries, gingivitis, or candidiasis.

Témoignages

“BYOME LABS assisted us in evaluating the microbiome impact of a new ingredient. The process was clear from start to finish, and the results allowed us to make more informed formulation decisions. The team is very responsive and informative, which made the collaboration truly enjoyable. We would not hesitate to use their services again.”

Marie, distributor of specialty ingredients

“Working with Byome Labs has been a real added value for our brand. Thanks to their precise analyses and expertise in microbiology, we have been able to test our products and obtain the ‘Microbiome Friendly’ label, which reinforces our credibility in the marketplace. Their strategic vision and marketing skills helped us turn scientific data into convincing arguments for our customers. A smooth and rewarding collaboration that clearly made all the difference! “

Sandra, DEMAIN BEAUTY

“Obtaining the Microbiome Respect label with the support of BYOME LABS was a real asset for our launch. Their team guided us at every stage, from testing to understanding the results, always with a clear and effective approach. This label strengthened our consumers’ trust and clearly differentiated our product in a highly competitive market. A simple, rigorous, and effective collaboration.”

Coralie Sabatier, BOPLUME

Sébastien, cosmetics group

The BYOME LABS approach

Our tests are designed to support pharmaceutical industry R&D and regulatory teams in the development and validation of oral health solutions.

At BYOME LABS, we:

Measure the impact of your products and/or ingredients on the oral microbiome, particularly in biofilm mode, which is the natural lifestyle of bacteria;
Offer fully customizable in vitro analyses tailored to your objectives, needs, and products;
Help brands develop targeted and effective solutions to restore a healthy oral microbiome and prevent oral diseases.

With 20 years of expertise in microbiology, we have mastered the culture of demanding microorganisms and guarantee robust, actionable data for your pharmaceutical and regulatory dossiers.

FAQ

Frequently Asked Questions

Why test a treatment on the oral microbiome? +

To prove that it respects or restores the balance of the oral flora, optimizes dental health and prevents infections.

Can you simulate an infection or oral imbalance? +

Yes, we reproduce dysbioses such as candidiasis or periodontitis in vitro to measure the corrective effect of the product.

How long does it take to get the results? +

On average 2 to 4 weeks depending on the protocol.

Thanks to our trusted partners

Contact us

Would you like to make an appointment or get more information?

You can reach us by filling in the contact form opposite or by e-mail at : info@byomelabs.com

BYOME LABS

Cité de l’Innovation
7 rue Auguste Rodin
28630 LE COUDRAY

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Byome Labs, French expert in pharmaceutical oral microbiome

Microbiology Laboratory and R&D Center – Clermont-Ferrand

We work with:

Pharmaceutical laboratories
Manufacturers of oral and dental medical devices
Suppliers of active ingredients

Testable products and applications

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