Vaginal and pharmaceutical microbiome

Assess the impact of your gynecological treatments on the vaginal microbiome

The vaginal microbiome: a key ecosystem for intimate health

The vaginal microbiome is a complex and dynamic ecosystem, dominated by bacteria of the genus Lactobacillus (L. crispatus, L. gasseri, L. iners, L. jensenii), representing up to 90% of the vaginal flora in healthy women (1,2).

These microorganisms perform essential functions:

Maintaining an acidic pH (≈4–4.5)
Protection against infections
Local immune support

When this balance is disrupted, dysbiosis can lead to:

Bacterial vaginosis: proliferation of anaerobes (Gardnerella vaginalis, Atopobium vaginae, Mycoplasma hominis), formation of a resistant biofilm, and elevated pH.
Candidiasis: Overgrowth of Candida albicans

These polymicrobial infections result in local symptoms (discharge, irritation, odor) and frequent recurrences due to biofilm resistance (1).

Maintaining the stability of the vaginal microbiome is a key challenge for pharmaceutical companies developing topical treatments, medical devices, and gynecological solutions.

Sources :

Romero R, Theis KR, Gomez-Lopez N, Winters AD, Panzer JJ, Lin H, et al. The Vaginal Microbiota of Pregnant Women Varies with Gestational Age, Maternal Age, and Parity. Microbiol Spectr. 17 août 2023;11(4):e0342922.
Abou Chacra L, Fenollar F, Diop K. Bacterial Vaginosis: What Do We Currently Know? Front Cell Infect Microbiol. 2021;11:672429.

At BYOME LABS, we study these interactions in vitro under conditions that faithfully reproduce the vaginal environment.

Our models allow you to:

Cultivate strains representative of the vaginal microbiome,
Simulate specific dysbioses (vaginosis, candidiasis),
Evaluate the antimicrobial, regulatory, or restorative effects of your products,
Observe the formation and degradation of biofilms, particularly during treatment or after the application of targeted active ingredients.

These approaches provide valuable data for understanding the microbial mechanisms involved in vaginal pathologies and optimizing the selectivity and tolerability of pharmaceutical treatments.

At BYOME LABS, we support the R&D and regulatory teams of pharmaceutical companies in the design, validation, and efficacy demonstration of gynecological solutions.

Témoignages

“BYOME LABS assisted us in evaluating the microbiome impact of a new ingredient. The process was clear from start to finish, and the results allowed us to make more informed formulation decisions. The team is very responsive and informative, which made the collaboration truly enjoyable. We would not hesitate to use their services again.”

Marie, distributor of specialty ingredients

“Working with Byome Labs has been a real added value for our brand. Thanks to their precise analyses and expertise in microbiology, we have been able to test our products and obtain the ‘Microbiome Friendly’ label, which reinforces our credibility in the marketplace. Their strategic vision and marketing skills helped us turn scientific data into convincing arguments for our customers. A smooth and rewarding collaboration that clearly made all the difference! “

Sandra, DEMAIN BEAUTY

“Obtaining the Microbiome Respect label with the support of BYOME LABS was a real asset for our launch. Their team guided us at every stage, from testing to understanding the results, always with a clear and effective approach. This label strengthened our consumers’ trust and clearly differentiated our product in a highly competitive market. A simple, rigorous, and effective collaboration.”

Coralie Sabatier, BOPLUME

Sébastien, cosmetics group

The BYOME LABS approach

We:

Measure the impact of your treatments or devices on the vaginal microbiome,
Use customizable in vitro models: balance or dysbiosis, pH variations, biofilm, anaerobic flora,
Provide reliable and reproducible results that can be used for your regulatory and clinical dossiers,
Base our studies on culturomics and advanced microbiology approaches for a detailed analysis of bacterial diversity.

With 20 years of expertise in microbiology, we have mastered the culture of fastidious microorganisms (strict anaerobes, yeasts, Lactobacillus) and transform your scientific evidence into compelling arguments for research, regulatory bodies, and clinical practice.

Objective: to demonstrate the preventive, corrective or restorative action of your solutions on vaginal microbial homeostasis, in the service of feminine intimate health.

FAQ

Frequently Asked Questions

Why test a treatment on the vaginal microbiome? +

To ensure that it preserves or restores the intimate balance, strengthens natural protection and limits the risk of infection.

Can you simulate bacterial vaginosis? +

Yes, we reproduce typical imbalances in vitro to measure the corrective effectiveness of the product.

How long does it take to get the results? +

On average 2 to 4 weeks depending on the protocol.

Thanks to our trusted partners

Contact us

Would you like to make an appointment or get more information?

You can reach us by filling in the contact form opposite or by e-mail at : info@byomelabs.com

BYOME LABS

Cité de l’Innovation
7 rue Auguste Rodin
28630 LE COUDRAY

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Byome Labs, French expert in pharmaceutical vaginal microbiome

Microbiology Laboratory and R&D Center – Clermont-Ferrand

We collaborate exclusively with:

• Pharmaceutical laboratories

• Manufacturers of dermatological medical devices

• Suppliers of active ingredients

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