Measuring the impact of your dermatological treatments on the skin microbiome
Skin microbiome and pharmaceuticals
We also work with you: pharmaceutical industry
Beyond cosmetics, BYOME LABS supports R&D and regulatory teams in the pharmaceutical industry.
With 20 years of expertise in microbiology, particularly in the pharmaceutical industry, we conduct studies within a strict and regulated framework for products that come into contact with the skin microbiome.
We also work on medical devices and various galenic formulations (wipes, gels, solutions, creams, etc.).
Our goal: to produce robust and reliable evidence to support your decisions.
Our methodology:
At BYOME LABS, we exclusively perform in vitro tests based on culturomics.
- Work on living microorganisms
- Culture of bacteria organized in biofilm, best reflecting real-world conditions
- In vitro cultures with wild or reference strains
- Reproduction of balanced and unbalanced microbiomes
- Ability to reproduce targeted dysbiosis (acne, atopic dermatitis, etc.) in vitro to evaluate the corrective effect of products
- Customized tests tailored to pharmaceutical treatments and ingredients
Towards microbiome-guided therapies
As research on the microbiome progresses, new therapeutic approaches are emerging. By modulating these microbial communities, it is becoming possible to consider innovative strategies for preventing and treating many diseases, whether acute or chronic. These advances underscore the importance of preserving this microbial balance to promote optimal health (Hou K et al. 2022, Choi I et al. 2012).
For laboratories and pharmaceutical manufacturers, understanding and positively influencing this balance is essential to optimize the action of topical treatments and limit adverse effects.
Switch to in vitro microbiome analysis
Are you developing an innovative dermatological treatment or a pharmaceutical active ingredient?
Contact BYOME LABS for a personalized and scientifically validated protocol.
Frequently asked questions
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Why test a treatment on the skin microbiome?
To prove that it respects or restores the skin’s balance, improves its effectiveness, and minimizes adverse effects.
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Can you simulate a skin condition?
Yes, we reproduce imbalances such as acne or atopic dermatitis in vitro to measure the corrective effect.
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How long does it take to get the results?
On average, 2 to 4 weeks depending on the protocol.
The link between skin microbiome and human health
The human body is a complex ecosystem hosting billions of microorganisms. The term “microbiome” refers to the totality of the genes of these microbial communities, which extend across almost every surface of the body. It is often referred to as the “second genome” because of its complementary role to that of the host. Its interactions can be beneficial, pathogenic, or neutral, thereby influencing human physiology.
With genetic diversity estimated to be between 50 and 100 times greater than that of the host, the microbiome regulates many processes (1,2).
One of the major functions of the microbiome is to protect the body against colonization by pathogens. This regulation is based on complex interactions between microorganisms, which maintain a stable balance. However, under certain conditions, beneficial bacteria can become pathogenic due to changes in the microbial environment.
Sources :
1. Hou K, Wu ZX, Chen XY, Wang JQ, Zhang D, Xiao C, et al. Microbiota in health and diseases. Signal Transduct Target Ther. 23 avr 2022;7(1):1‑28.
2. Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. avr 2012;13(4):260‑70.
3. Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW. Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies. Chem Rev. 11 janv 2023;123(1):31‑72.
Testable products and applications
Dermatological creams and gels
Topical healing or antiseptic solutions
Wipes and bandages
Pharmaceutical active ingredients (probiotics, prebiotics, plant extracts, etc.)
Benefits for your projects
Scientific evidence tailored to the pharmaceutical sector
Differentiation in your regulatory dossiers
Risk reduction in clinical development
Solid data for your microbiome-friendly claims
Assessment of the corrective effect in cases of dysbiosis
BYOME LABS, French expert in the pharmaceutical skin microbiome
We work with:
Pharmaceutical companies
Manufacturers of dermatological medical devices
Suppliers of active ingredients
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