{"id":8344,"date":"2025-12-30T16:10:16","date_gmt":"2025-12-30T15:10:16","guid":{"rendered":"https:\/\/byomelabs.com\/?p=8344"},"modified":"2025-12-30T16:10:16","modified_gmt":"2025-12-30T15:10:16","slug":"byome-labs-expertise-in-understanding-and-targeting-acne-related-dysbiosis","status":"publish","type":"post","link":"https:\/\/byomelabs.com\/en\/news\/byome-labs-expertise-in-understanding-and-targeting-acne-related-dysbiosis\/","title":{"rendered":"A specialist in the skin microbiome, BYOME LABS leverages its unique expertise to drive cosmetic innovation."},"content":{"rendered":"

A specialist in the skin microbiome, BYOME LABS leverages its unique expertise to drive cosmetic innovation.<\/em>
With over 20 years of combined experience, the analysis of 5,000 sequencings and 250 scientific studies, our team has already supported 40 clients and conducted more than 100 projects dedicated to evaluating the impact of cosmetics on the microbiome. Through our in vitro tests, we help brands better understand and manage microbial imbalances, particularly those linked to acne, in order to develop skincare products that are both more effective and respectful of the skin.<\/em><\/p>\n

Vulgar acne is a common dermatological condition primarily affecting adolescents and young adults (1,2). Its impact goes beyond aesthetics, as it can significantly affect quality of life and have serious psychological consequences (1,3). Historically, acne pathogenesis has been associated with several key factors, including excessive sebum production and follicular hyperkeratinization. However, recent research has highlighted the crucial role of the skin microbiome and its imbalance in the development and severity of this condition (1,3).<\/p>\n

Role of microorganisms involved in acne<\/strong><\/h3>\n

Cutibacterium acnes<\/em> (C. acnes<\/em>) is a Gram-positive anaerobic bacterium that is naturally present on the skin, particularly in lipid-rich sebaceous glands (1). Certain Cutibacterium acnes<\/em> strains, due to their pro-inflammatory properties and their ability to form biofilms, are now considered opportunistic agents in inflammatory acne (2).<\/p>\n

Acne is not linked to a higher quantity of C. acnes<\/em>, but rather to an imbalance between its phylotypes.<\/p>\n

\"\"<\/p>\n

Indeed, the comparison between healthy skin and acne-prone skin highlights the central role of Cutibacterium acnes<\/em> in acne pathogenesis. On normal skin, C. acnes<\/em> exists as a commensal organism, in balance with other microorganisms such as bacteria, fungi, and viruses, without triggering inflammation. Immune homeostasis and barrier function are maintained. In contrast, in acne-prone skin, certain C. acnes<\/em> strains proliferate excessively. They form protective biofilms (A), induce abnormal keratinocyte proliferation and differentiation accompanied by epidermal inflammation (B), stimulate sebocyte lipogenesis (C), and disrupt the skin immune response (D). This cascade of events leads to chronic inflammation and the formation of the characteristic acne lesions (3).<\/p>\n

    \n
  • Staphylococcus and its role in microbial balance<\/strong><\/li>\n<\/ul>\n

    Among other bacteria influencing acne, some species of the genus Staphylococcus<\/em> play a modulatory role. Staphylococcus epidermidis<\/em>, for example, is a common skin bacterium that can limit the proliferation of C. acnes<\/em> by producing natural antimicrobial substances (1,3). S. epidermidis<\/em> coexists with C. acnes<\/em> in acne lesions and suppresses the inflammation induced by C. acnes<\/em>. Indeed, through the succinic acid it produces, S. epidermidis<\/em> blocks certain defense receptors (TLRs) on the surface of keratinocytes. The release of inflammatory mediators such as IL-6 and TNF-\u03b1 is reduced, which attenuates the inflammatory reaction triggered by C. acnes<\/em> (4).<\/p>\n

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    • \n

      Malassezia: a fungus involved in certain forms of acne<\/strong><\/p>\n

      While bacteria are often highlighted in acne pathogenesis, the role of certain fungi, notably Malassezia<\/em> spp., should also be considered. This lipophilic microorganism is naturally present on the skin and can be involved in conditions such as seborrheic dermatitis. Studies have shown that Malassezia<\/em> can be isolated from acne lesions, suggesting a potential influence in certain forms of acne (5).<\/p>\n<\/li>\n<\/ul>\n

      Acne treatments and their impact on the microbiome<\/strong><\/h3>\n

      Conventional acne treatments include topical retinoids, benzoyl peroxide, and oral antibiotics. While these approaches are effective at reducing inflammation and bacterial proliferation, they can also disrupt the balance of the skin microbiome. Furthermore, prolonged use of antibiotics can lead to a significant increase in bacterial resistance, affecting both C. acnes<\/em> and Staphylococcus epidermidis<\/em>, which raises major public health concerns (6,7).<\/p>\n

      Indeed, acne treatments strongly influence the skin microbiome. Benzoyl peroxide, through its non-specific oxidative action, effectively reduces C. acnes<\/em> but may also impact other skin microorganisms, with effects on microbial diversity that remain poorly understood (2). Other approaches, such as salicylic acid and phototherapy, may reduce the prevalence of dominant species, contributing to the restoration of a more balanced microbial diversity (2).<\/p>\n

      Given the limitations of conventional treatments, new therapeutic approaches are emerging that target the skin microbiome while preserving its balance. Certain probiotic strains, notably from the genera Lactobacillus<\/em> and Bifidobacterium<\/em>, have shown beneficial effects on skin health. They help support a balanced microbial flora and positively modulate the skin\u2019s immune response. Several recent studies suggest that topical application of probiotics could improve conditions such as acne by stimulating ceramide production, reducing inflammation, and enhancing protection against pathogenic microorganisms (6). Oral probiotics also appear effective in reducing lesion counts and inflammation through the gut-skin axis (6). Other approaches include bacteriophages that specifically target pathogenic C. acnes<\/em> strains without affecting beneficial bacteria (6). Finally, postbiotics, which are bacterial metabolites, and antimicrobial peptides are being studied for their anti-inflammatory effects and their ability to restore skin homeostasis (6).<\/p>\n

      BYOME LABS\u2019 approach: innovation serving the microbiome<\/strong><\/h3>\n

      At BYOME LABS, we leverage our 20 years of combined expertise in the skin microbiome to support cosmetic, dermocosmetic, and pharmaceutical brands. We develop and conduct in vitro tests based on culturomics approaches, allowing us to evaluate the impact of products from different formulations on microorganisms representative of the skin microbiome. To design the best study models, we rely on the latest scientific data, including genomic sequencing studies and recent publications in the field. This enables us to recreate laboratory models of dysbiosis, including acne, and observe the action of your product in this specific context. You thus obtain scientific evidence demonstrating that your product has a preventive, corrective effect or simply preserves the balance of the skin microbiome in an acne context.<\/p>\n

      References :<\/strong><\/h3>\n
        \n
      1. Dessinioti C, Katsambas A. The Microbiome and Acne: Perspectives for Treatment. Dermatol Ther. 1 janv 2024;14(1):31\u201144.<\/li>\n
      2. Podwojniak A, Tan IJ, Sauer J, Neubauer Z, Rothenberg H, Ghani H, et al. Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments. J Eur Acad Dermatol Venereol. avr 2025;39(4):793\u2011805.<\/li>\n
      3. Huang C, Zhuo F, Han B, Li W, Jiang B, Zhang K, et al. The updates and implications of cutaneous microbiota in acne. Cell Biosci. 21 juin 2023;13(1):113.<\/li>\n
      4. Fourni\u00e8re M, Latire T, Souak D, Feuilloley MGJ, Bedoux G. Staphylococcus epidermidis and Cutibacterium acnes: Two Major Sentinels of Skin Microbiota and the Influence of Cosmetics. Microorganisms. 7 nov 2020;8(11):1752.<\/li>\n
      5. Song YC, Hahn HJ, Kim JY, Ko JH, Lee YW, Choe YB, et al. Epidemiologic Study of Malassezia Yeasts in Acne Patients by Analysis of 26S rDNA PCR-RFLP. Ann Dermatol. ao\u00fbt 2011;23(3):321\u20118.<\/li>\n
      6. Nied\u017awiedzka A, Micallef MP, Biazzo M, Podrini C. The Role of the Skin Microbiome in Acne: Challenges and Future Therapeutic Opportunities. Int J Mol Sci. 24 oct 2024;25(21):11422.<\/li>\n
      7. \u00a0O\u2019Neill AM, Nakatsuji T, Hayachi A, Williams MR, Mills RH, Gonzalez DJ, et al. Identification of a human skin commensal bacterium that selectively kills Cutibacterium acnes. J Invest Dermatol. ao\u00fbt 2020;140(8):1619-1628.e2.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

        Through our in vitro tests, we help brands better understand and manage microbial imbalances, particularly those linked to acne, in order to develop products that are more effective and respectful.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[38,27],"tags":[],"class_list":["post-8344","post","type-post","status-publish","format-standard","hentry","category-byome-derma","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/posts\/8344","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/comments?post=8344"}],"version-history":[{"count":0,"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/posts\/8344\/revisions"}],"wp:attachment":[{"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/media?parent=8344"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/categories?post=8344"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/byomelabs.com\/en\/wp-json\/wp\/v2\/tags?post=8344"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}